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A new skeletal expansion approach to make γ-lactam pharmacophores by Cu-catalyzed difluorocarbene insertion into azetidines. It turns out that some γ-lactam scaffolds are harder to access than azetidines. Just accepted in @angewandtechemie.bsky.social. onlinelibrary.wiley.com/doi/10.1002/...
Apr 7, 2025, 5:13 PM