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A nice summary of the current state of ML methods for fitness prediction, although I totally disagree with this bullet and think structure is more useful for design than MSAs, if I had to pick one
May 8, 2025, 6:19 AM
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"alt": "\"The top-performing models for Spearman correlation (mutation effect prediction focus) aren't necessarily the best based on NDCG (design focus). Generally, structural information provides an edge for the former, while MSAs appear critical for the latter.\"",
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