ATProto Browser

{
  "text": "We've been interested in using Baker Lab's ProteinMPNN to design/diversify mAb seqs w/ structure data. Unfortunately its output seqs aren't very antibody-like & don't refold into the target conformation as often as we'd like",
  "$type": "app.bsky.feed.post",
  "embed": {
    "$type": "app.bsky.embed.images",
    "images": [
      {
        "alt": "Figure 1. ProteinMPNN does not generate antibody-like sequences unless ensembled with the\nantibody language model AbLang. A) V-gene sequence identity of all designs to the most similar\ngermline. Therapeutic antibody sequences were fetched from TheraSAbDaB on X February 2025. B)\nRecovery of the starting sequence. C) Recovery of antigen-binding residues in the CDRs. Y -axis\ndenotes frequency. Top to bottom: ProteinMPNN, AbMPNN, ProteinMPNN+AbLang, AbLang, ESM.\nD) Recovery of the starting conformation of CDRH3. Mann-Whitney U test results: n/s: not significant;\n*: 0.05≤p<0.5; **: 0.005≤p<0.05; ***: p<0.005.",
        "image": {
          "$type": "blob",
          "ref": {
            "$link": "bafkreidu55etii2whdvzp5e3l52xulwgtlkrf45xs2d3674gtn2tazb62e"
          },
          "mimeType": "image/jpeg",
          "size": 465191
        },
        "aspectRatio": {
          "width": 1892,
          "height": 870
        }
      }
    ]
  },
  "langs": [
    "en"
  ],
  "reply": {
    "root": {
      "cid": "bafyreice3gjxwhqqvosjj3ljzjgsuounsbynhhoziiuca4arabekevwute",
      "uri": "at://did:plc:it7vw4dejlm32tzqsdqzagd4/app.bsky.feed.post/3lp7wr4buxc2f"
    },
    "parent": {
      "cid": "bafyreice3gjxwhqqvosjj3ljzjgsuounsbynhhoziiuca4arabekevwute",
      "uri": "at://did:plc:it7vw4dejlm32tzqsdqzagd4/app.bsky.feed.post/3lp7wr4buxc2f"
    }
  },
  "createdAt": "2025-05-15T16:30:14.106Z"
}