ATProto Browser

{
  "text": "The ProteinMPNN+AbLang combo outperforms ProteinMPNN on basically all metrics you can think of. We also tested 96 trastuzumab CDRH3 designs using each method: ProteinMPNN+AbLang got 36 HER2 binders, ProteinMPNN alone got 3, AbLang got 1",
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        "alt": "Fig 2. Ensembling ProteinMPNN and AbLang improves identification and design of trastuzumab\nvariants. A) ROC curve of ~35,000 trastuzumab mutants previously measured by deep mutational\nscanning. Per-residue probabilities were calculated using either the crystal structure with a fully masked\nCDRH3, or the complete heavy chain Fab (for ESM) or VH (for AbLang) with fully masked CDRH3.\nB) Distribution of experimentally measured HER2 binding affinities of designs generated by\nProteinMPNN alone, AbLang alone, or both methods ensembled together. A total of ninety-six designs\nwere generated using each method. Nonbinders were omitted from this chart.",
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  "createdAt": "2025-05-15T16:30:14.108Z"
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