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Online now: Engineered thermoswitch in the baculovirus expression vector system for production of virus-like particle vaccines with minimized baculovirus contaminants
May 12, 2025, 3:15 PM
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"title": "Engineered thermoswitch in the baculovirus expression vector system for production of virus-like particle vaccines with minimized baculovirus contaminants",
"description": "This work presents an innovative baculovirus expression system for virus-like-particle (VLP) vaccine production. A genetic thermoswitch was engineered in the baculovirus expression vector (BacFreets) to regulate baculovirus particle production. Temperature elevation from 27°C to 33°C results in a multilog reduction of co-produced baculovirus contaminants in the upstream VLP production phase."
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"createdAt": "2025-05-12T15:15:10Z"
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