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    "text": "A novel MRI-based model predicts perineural invasion in cholangiocarcinoma\n\nby Qi Z, Yuan H (...) Li D et 7 al. in World J Surg Oncol #Surgery #SurgSky #GeneralSurgery #MedSky\n\n🪡 read our summary here\n📖 read the article: ",
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        "uri": "https://wjso.biomedcentral.com/articles/10.1186/s12957-025-03819-w",
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        "title": "An MRI-based fusion model for preoperative prediction of perineural invasion status in patients with intrahepatic cholangiocarcinoma - World Journal of Surgical Oncology",
        "description": "Background To develop and validate an MRI-based fusion model for preoperative prediction of perineural invasion (PNI) status in patients with intrahepatic cholangiocarcinoma (ICC). Methods A retrospective collection of 192 ICC patients from three medical centers (training set: n = 147; external test set: n = 45) was performed. Patients were classified into the PNI-positive and PNI-negative groups based on postoperative pathological results. After image preprocessing, a total of 1,197 features were extracted from T2-weighted imaging (T2WI). Feature selection was performed, and a radiomics model was constructed using machine learning algorithms, followed by SHapley Additive exPlanations (SHAP) visualization. Subsequently, a deep learning model was constructed based on the pre-trained ResNet101, with Gradient-weighted Class Activation Mapping (Grad-CAM) used for visualization. Finally, a fusion model incorporating deep learning, radiomics, and clinical features was developed using logistic regression, and visualization was performed with a nomogram. The predictive performance of the model was evaluated based on the area under the curve (AUC), calibration curves, and decision curve analysis (DCA). Results The fusion model, which integrates deep learning signature, radiomics signature, and two clinical features, demonstrated strong discrimination for PNI status. In the training set, the AUC was 0.905, with an accuracy of 0.823; in the external test set, the AUC was 0.760, with an accuracy of 0.778. Visualization methods provided support for the practical application of the model. Conclusion The fusion model aids in the preoperative identification of PNI status in patients with ICC, and may help guide clinical decision-making regarding preoperative staging and adjuvant therapy."
      }
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      "en"
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        "features": [
          {
            "uri": "https://stitches.today/2025/05/04/a-novel-mri-based-model-predicts-perineural-invasion-in-cholangiocarcinoma",
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    "createdAt": "2025-05-04T02:23:09.927540+00:00"
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