ATProto Browser

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  "text": "OGT touches many aspects of cell and molecular biology. We show that OGT restrains the DNA demethylation activity of the TETs, and guards against the reactivation of repressed endogenous retroviruses.\nwww.nature.com/articles/s41...\n@faulknerlab.bsky.social @biomodal.bsky.social @lji.org #glycotime",
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      "title": "OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide - Nature Structural & Molecular Biology",
      "description": "Here the authors show that the disruption of OGT expression in mouse embryonic stem cells unleashes TET activity, causing genome-wide decreases in DNA methylation and increases in 5-hydroxymethylcytos..."
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